Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system

Here is another interesting paper on Lidocaine vs Articaine (Septocaine):

Endodontology
Editor: Larz S. W. SPåNgberg
Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system

Jeffrey Berlin, DDS, MS a [MEDLINE LOOKUP] John Nusstein, DDS, MS b * [MEDLINE LOOKUP] Al Reader, DDS, MS c [MEDLINE LOOKUP] Mike Beck, DDS, MA d [MEDLINE LOOKUP] Joel Weaver, DDS, PhD e [MEDLINE LOOKUP]

Abstract

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Objective The purpose of this prospective, randomized, double-blind study was to compare the anesthetic efficacy of the intraligamentary injection of 4% articaine with 1:100,000 epinephrine and of 2% lidocaine with 1:100,000 epinephrine, administered with computer-controlled local anesthetic delivery system, in mandibular posterior teeth.

Study design Using a crossover design, intraligamentary injections of 1.4 mL of 4% articaine with 1:100,000 epinephrine and of 1.4 mL of 2% lidocaine with 1:100,000 epinephrine were randomly administered with a computer-controlled local anesthetic delivery system, in a double-blind manner on the mesial and distal aspects of a mandibular first molar, at 2 separate appointments to 51 subjects. A pulp tester was used to test for anesthesia, in 2-minute cycles for 60 minutes, of the mandibular first and second molars and second premolar. Anesthesia was considered successful when 2 consecutive 80 readings (highest output) were obtained within 20 minutes.

Results Successful pulpal anesthesia was obtained 86% of the time for the first molar using the articaine solution and 74% of the time using the lidocaine solution. There were no significant differences (P>.05) between the articaine and lidocaine solutions. The mean onset times of pulpal anesthesia for the first molar were 1.3 minutes with articaine solution and 2.2 minutes with lidocaine solution. Duration of pulpal anesthesia for the first molar was 34 minutes for the articaine solution and 31 minutes for the lidocaine solution.

Conclusion The efficacy of 4% articaine with 1:100,000 epinephrine was similar to the efficacy of 2% lidocaine with 1:100,000 epinephrine for intraligamentary injections.

Publishing and Reprint Information

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• ^aFormerly graduate student, Department of Endodontics. Currently private practice, endodontics, Los Angeles, Calif
• ^bAssistant Professor, Department of Endodontics
• ^cProfessor and Program Director of Graduate Endodontics, Department of Endodontics
• ^dAssociate Professor, Department of Oral Biology
• ^eProfessor and Program Director of Anesthesiology, Department of Oral Surgery, Oral Pathology, and Anesthesiology
• This article was adapted from a thesis submitted by Dr Berlin in partial fulfillment of the requirements for the MS degree at The Ohio State University. A portion of this article was presented at the 2003 Annual Session of the American Association of Endodontists, Tampa, Fla. This study was supported by research funding from the Graduate Student Research Fund, Graduate Endodontics, The Ohio State University.
• ^*Reprint requests: Dr John Nusstein, Department of Endodontics, College of Dentistry, 305 W 12th Avenue, The Ohio State University, Columbus, Ohio 43218
• Email address: nusstein.1@osu.edu (John Nusstein)
• Columbus, Ohio
  THE OHIO STATE UNIVERSITY
• Submitted June 9, 2004.
• Accepted November 2, 2004.